Why Teams Use Fermenta
Today’s ADME toolbox is powerful but noisy. Hepatocytes and pooled microsomes vary lot-to-lot and vendor-to-vendor, forcing expensive reruns, conflicting Clint rankings, and delays in lead-optimization and IND-enabling packages. When transporters drive exposure or DDIs, the standard metabolism assays often can’t show the full picture.
Current Tools are Noisy
Hepatocytes and microsomes vary lot-to-lot and vendor-to-vendor, forcing costly reruns and conflicting Clint rankings
We make the Biology Behave
Proprietary membrane and enzyme engineering methods stabilize CYPs and transporters while maintaining high catalytic activity.
You Save Money & Time
Assay-ready plates go from freezer → incubator → LC-MS, shaving weeks off ADME cycles and reducing CRO spend.
Key Features
Lot-to-Lot
Variability
Transporter-Aware
Metabolism
Assay-Ready,
Lyophilized Format
Cleaner Spectra vs.
Pooled Microsomes
Under the Hood
We reconstitutes human CYP450s, CPR, and optional transporters into artificial cells, using design rules from research to stabilize activity and reduce variability. Each panel well acts like a tiny hepatic compartment.
Inside Each Well:
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Recombinant human CYP + CPR
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NADPH regeneration system
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Optional UGT/add-ons for Phase I→II workflows
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Lipid compositions chosen to maximize turnover and stability
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Tunable membrane porins to control cofactor/small molecule flux
The result is a plug-and-play system that captures key hepatic mechanisms while staying reproducible, modular, and shelf-stable.
Where Fermenta Shines
High-Risk DDI Candidates
Evaluate CYP3A4- and transporter-driven interactions earlier, using transporter-aware artificial cells instead of stitching together separate assays.
Programs with Noisy Data
Replace variable hepatocyte lots with defined artificial cells to rank-order clearance and understand unexpected exposure trends.
Differentiated ADME Services
Offer clients premium, transporter-aware metabolism panels as an upsell over commodity microsome-based assays.
